Knee function and osteoarthritis 10 years after operative and nonoperative treatment after anterior cruciate ligament rupture: A 10-year follow-up of the Delaware-Oslo ACL Cohort Study

Anterior cruciate ligament (ACL) injuries can be managed with or without ACL reconstruction (ACLR). The existing literature is sparse but has generally not concluded on superior outcomes after ACLR compared to rehabilitation alone. More high-quality studies evaluating outcomes after different treatment courses, especially at long-term following injury, are needed.

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Formell tittel

Knee function and osteoarthritis 10 years after operative and nonoperative treatment after anterior cruciate ligament rupture: A 10-year follow-up of the Delaware-Oslo ACL Cohort Study

Formål

  1. Define KOOS and IKDC2000 cutoff values for patient acceptable symptomatic state (PASS) or treatment failure at 10 year after ACL- rupture.
  2. Conduct a systematic review on measurement properties for muscle strength and functional performance tests in persons with ACL and meniscus injury.
  3. Describe and compare the difference in symptomatic and radiographic knee osteoarthritis, patient-reported outcomes scores, muscle strength and functional performance tests and participation in sports between treatment groups 10 years after surgical and non-surgical treatment of ACL-rupture.
  4. Compare patient-reported knee function preoperatively and 10 years postoperatively between patients who followed preoperative and postoperative rehabilitation and patients from national ACL registers who received usual care.

Prosjektbeskrivelse

The project is a 10-year follow-up of the Delaware-Oslo ACL Cohort study. This is a prospective cohort study on nonprofessional competitive athletes with anterior cruciate ligament (ACL) injury from two sites in Delaware (n=150) and in Oslo (n=150).

Patients were included at baseline between 2007 and 2012. The data collection for the 10-year follow-up started 2017 and will be finished 2023. All patients followed a standardized treatment algorithm, implying a 5-week protocol-based rehabilitation program before study inclusion, followed by early ACLR plus rehabilitation or rehabilitation with or without delayed ACLR. Patients underwent a high-quality rehabilitation program and were tested at inclusion and after the rehabilitation period.

Patients were additionally tested 6 months, 1 year, 2 years and 5 years after treatment choice.

The Delaware-Oslo ACL cohort study follows cohorts in both Delaware (n = 150) and Oslo (n = 150). Professor Lynn Snyder-Mackler is the leader of the project and responsible for the American cohort of the project at the University of Delaware. Professor May Arna Risberg is responsible for the Norwegian cohort of the project, which is formally anchored at Oslo University Hospital. The study is funded by the National Institutes of Health through grants R37HD37985.