Full title: Knee function and osteoarthritis 10 years after operative and non-operative treatment of anterior cruciate ligament injury: A 10-year follow-up of the Delaware-Oslo ACL Cohort Study
Purpose
- Define KOOS and IKDC2000 cutoff values for patient acceptable symptomatic state (PASS) or treatment failure 10 years after ACL rupture.
- Conduct a systematic review of measurement properties for muscle strength and physical performance tests in individuals with ACL and meniscus injuries.
- Describe and compare differences in symptomatic and radiographic knee osteoarthritis, patient-reported outcome measures, muscle strength and physical performance tests, and participation in sports between treatment groups 10 years after surgical and non-surgical treatment of ACL rupture.
- Compare patient-reported outcome measures for knee function preoperatively and 10 years postoperatively between patients who followed preoperative and postoperative rehabilitation in the study’s treatment algorithm and patients from the National ACL Registry who received surgical treatment.
Project description
The project is a 10-year follow-up of the Delaware-Oslo ACL Cohort Study. This is a prospective cohort study of patients with ACL rupture at level I and II, recruited from two sites: Delaware (n=150) and Oslo (n=150).
Patients were included between 2007 and 2012. Data collection for the 10-year follow-up began in 2017 and was completed in 2023. All patients followed a standardized treatment algorithm, which included a 5-week protocol-based rehabilitation program before a decision was made together with the patient regarding operative or non-operative treatment, followed by early ACLR plus rehabilitation (postoperative) or continuation of rehabilitation alone. All patients underwent a high-quality rehabilitation program and were tested at inclusion and after the rehabilitation period, followed by follow-up tests at 6 months, 1 year, 2 years, 5 years, and 10 years.
Professor Lynn Snyder-Mackler is the principal investigator (PI) and is responsible for the Delaware cohort at the University of Delaware. Professor May Arna Risberg (co-PI) is responsible for the Norwegian (Oslo) cohort, which is formally anchored at Oslo University Hospital. The study has been funded by the National Institutes of Health for 10 years, including through project number R37HD37985.
